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反复自然流产患者外周血孕激素诱导阻断因子及Th1/Th2型细胞因子表达的研究
黄山鹰,唐国玲,戴宇,刘庆芝,姚吉龙,都红蕾
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摘要:
目的 探讨反复自然流产(recurrent spontaneous abortion,RSA)患者血清中孕激素诱导阻断因子(PIBF)及Th1/Th2型细胞因子的异常表达及其临床意义。方法 采用酶联免疫吸附法检测94例RSA患者血清中PIBF和Th1(IL-2、TNF-α、IFN-γ)/Th2(IL_10)型细胞因子水平,同时以72例正常未孕妇女及92例正常健康早孕妇女作为对照。结果 3组研究对象外周血血清中各细胞因子的表达水平组间比较均有显著性差异,RSA组血清中IL-2、TNF-α、IFN-γ的水平显著高于正常健康早孕组,差异有统计学意义(P<0.05),而PIBF、IL-10水平显著低于正常健康早孕组,差异有统计学意义(P<0.05)。结论 RSA患者血清中PIBF表达水平降低可导致反复自然流产,可作为预测反复自然流产的检测指标;Th1/Th2型细胞因子间平衡的改变与反复自然流产有关,而PIBF在调节Th1/Th2型细胞因子的平衡中起重要的作用。
关键词:  反复自然流产  孕激素诱导阻断因子  Th1/Th2型细胞因子  血清
DOI:0
基金项目:
Study of progesterone-induced blocking factor and Thl/Th2 cytokines expression in serum in recurrent spontaneous abortion
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Abstract:
Objective To determine the concentrations of progesterone-induced blocking factor and T helper-1 type(Th1)/T helper-2 type(Th2) cytokine in serum of patient with recurrent spontaneous abortion(RSA)and to study their clinical significance.Methods The PIBF、IL-2、TNF-α、IFN-γand IL-10 concentrations in serum of 94 RSA patients were measured by enzyme-linked immunosorbent assay(ELISA).72 nonpregnant woman and 92 normal pregnant women were controls .Results IL-2、TNF-α、IFN-γ concentrations in serum of RSA were significantly higher than those in normal pregnant women (P<0.05),while PIBF、IL-10 concentrations in RSA group were lower than those in normal pregnant women (P<0.05).Conclusion The changes obviously decrease of expression of PIBF in serum of RSA group maybe one of the important cause of RSA.Thl/Th2 balance was related to RSA, it maybe one of the important routines transferring RSA.PIBF plays an important role in regulating the balance of Thl/Th2 cytokines
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