Bronchial asthema is a chronic pulmonary disease participated by many sorts of immunocytes and cytokines, characterized by reversibility airway obstruction, airway hyperreactivity and airway inflammation, additionally, it has certain genetic predisposition. Recent studies suggest that gene polymorphism plays a significance role in the cause of bronchial asthma. The research of gene polymorphism in bronchial asthma is useful to understand the molecular pathophysiology of bronchial asthema and explore the therapeutic targets. This article reviews several susceptibility gene of asthma.