Objective To observe Hypothyroidism of women at reproductive age in Xingtai city.For the women of reproductive age prepregnancy check,and to provide a scientific basis for eugenics. Methods 1058 women of reproductive age enrolled were continuous collection of our hospital outpatient. The markers of thyroid function,such as free thyroxine(FT4),thyroid stimulating hormone(TSH),and thyroid peroxidase antibody(TPO-Ab) were determined with the electrochemiluminescence immunoassay(Roche MYEGOI).Selection of hypothyroidism or subclinical hypothyroidism women as the observation group,the incidence of thyroid disfunction in different groups was analyzed. Results The incidence of hypothyroidism increased with age. The difference was statistically significant. Conclusion The incidence of hypothyroidism in reproductive age women in Xingtai is increasing with age.It is necessary to test the project before pregnancy