objective to pegylated interferon alpha -2a (PEG-IFN alpha -2a) Leigh Bhave Lin curative effect in the treatment of chronic hepatitis C were analyzed. The object selection method in 60 cases of chronic hepatitis C patients in our hospital as the research and analysis of the time is from January 2013 to January 2017, and they were randomly divided into two groups, namely control group and observation group. The control group were treated with interferon (Leigh Bhave Lin interferon alfa-2b injection) for treatment, the observation group used PEG-IFN alpha -2a combined with Leigh Bhave Lin therapy. Compared two groups of patients with virus should be The incidence of adverse reactions and a sustained virological response. Results of the observation group (SVR), early virological response (EVR) and virological nonresponders (NR) were better than the control group; the observation group of adverse reaction rate was 16.67%, the adverse reaction rate in the control group was 46.67%, two groups of adverse reactions the observation group was better than the control group, and P<0.05, the difference was statistically significant. Conclusion PEG-IFN in patients with chronic hepatitis C alpha -2a combined with Leigh Bhave Lin treatment, the clinical efficacy, side effects are relatively small, with further promotion and Application value