| 摘要: |
| 【目的】探讨影响新生儿缺氧缺血性脑病(hypoxic—ischemic encephalopathy，HIE)发病的临床因素，为制定干预措施提供依据。
【方法】回顾性分析我院2013年1月至2017年3月HIE患儿50例，通过分析母妊娠期病史及分娩情况,并以我院同期出生新生儿为对照，采用logistic回归法分析多种临床因素对新生儿缺血缺氧性脑病发生的影响。【结果】两组中发现胎心监护异常、胎盘异常、妊娠高血压或子痫、母体合并产前发热、脐带异常、1 min Apgar评分<3分及5 min Apgar评分<5分与HIE发生有密切关系(P<005)。【结论】新生儿缺血缺氧性脑多因素相关，孕期及产时有效干预有助于预防新生儿缺血缺氧性脑病。 |
| 关键词: 新生儿 缺氧缺血性脑病 多因素分析 |
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| 基金项目: |
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| The pathogenesis of neonatal hypoxic ischemicencephalopathy related factors of research |
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| Abstract: |
| Objective :To investigate the clinical factors of neonatal hypoxic ischemic encephalopathy (hypoxic - ischemic encephalopathy, HIE), to provide evidence for intervention measures.Methods :Retrospective analysis 50 cases of HIE,which in January 2013 to March 2017, by analyzing the history of the mother during pregnancy and childbirth, and the same period in our hospital neonatal birth control, using multiple logistic regression analysis of clinical factors on the effect of neonatal hypoxic ischemia encephalopathy occurred. Results :The two groups were found in cardiac care, an abnormal amniotic fluid pollution, placenta, gestational hypertension or eclampsia, maternal prenatal fever, abnormal umbilical cord, 1 min Apgar score < 3 score and 5 min Apgar score < 5 score points there is a close relationship with HIE (P < 0.05). Conclusion: The newborn hypoxic ischemia encephalopathy may be associated with multivariate maternal and fetal factors, pregnancy and intrapartum effective intervention may help prevent neonatal hypoxic ischemia encephalopathy |
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